【摘 要】
：
OBJECTIVE: To evaluate the efficacy of computed tomography(CT) guided cryoablation in treatment of lung cancer.METHODS: From Jan 2002 to Apr 2006, 816 patients with primary or metastatic lung cancer w
【机 构】
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Lung Cancer Research Institute & Oncology Fuda Cancer Hospital China
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
OBJECTIVE: To evaluate the efficacy of computed tomography(CT) guided cryoablation in treatment of lung cancer.METHODS: From Jan 2002 to Apr 2006, 816 patients with primary or metastatic lung cancer were treated with cryoablation.A total of 1139 cryoablations were done for 1014 lesions, which with mean diameter of 6.3±0.4 cm (ranged from 1.0 to 25.0cm).Freeze-thaw cycle was set as 15 min of freezing at-140±10*3f with argon and 5 min of thawing at 15±5*3f with helium.Three freeze-thaw cycles were performed during each cryoablation.Recheck CT or PET/CT and reappraise Karnofsky Performance Status (KPS) every 1-3 monthes, and followed up every 3 months.RESULTS: There were 1006 lesions (68.3%) decreased in size, and with mean size reducing from 4.7±0.3 cm to 3.5±0.4 cm in diameter, (CR+PR+SD) 91.2%.Tumor activity of all lesions decreased or deactivated.Paitents showed obvious improvement after treatment, with Karnofsky Performance Status (KPS) rising form 77.8±9.3 to 85.92±7.8(t=4.368, P=0.000).Among 202 patients with peripheral lung cancer and chest wall invasion who complained chest pain pre-cryoablation, 40 patients (19.8%) showed complete pain relief after cryoablation and 124 patients (61.4%)showed partially pain relief, respectively.The overall survival rates were 70.2%% for 1-year and 54.1% for 2-year.The 1-year survival rate were 100.0%, 93.5%, 84.1%, 57.6% and 49.0%, and 2-year survival rate were 100.00%*81.36%*71.27%, 48.19% and 38.48% for patients in stage Ⅰ, stage Ⅱ, stage Ⅲ and stage Ⅳ of primary lung cancer and metastatic lung cancer, respectively.CONCLUSIONS: CT guided cryoablation showed some efficacy in controlling the progress of lung cancer and may contribute to pain relief and prolong survival for lung cancer patients.
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