Expression of BMI-1 in human eervical tissue-a diagnostic and prognosis marker in patients with uter

• 作 者: XinZhang;ChuanxinWang;ChengbaoZhu;JianZHANG;ShifengKan;LumoDu;WeiLi;LiliWang;ShunWang;
• 机 构: Department of Clinical Laboratory,Qilu Hospital, Shandong University,Jinan 250012,China
• 出 处: 中华医学第九次全国检验医学学术会议暨中国医院协会临床检验管理专业委员会第六届全国临床检验实验室管理学术会议
• 发表日期: 2011年期

@@ Uterine cervical cancer(UCC)remains the second most frequent malignancy in women worldwide.HPV infection alone is not sufficient to induce malignant changes，suggesting additional host genetic factors may be involved in the development and progression of UCC. B-cell-specific Moloney murine leukemia virusintegration site 1(ami—11 is a member ofpolycomb group，which participates in axial patteming，hematopoiesis， cell cycle regulation， and senescence.Recently，overexpression of Bmi-1 has been reported in various human cancers and proved to be associated with poor survival.The aim of this study was to investigate the expression of Bmi-1 protein in (UCC)and explore its associations with clinicopathological factors and prognosis.