【摘 要】
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Atherosclerosis is a chronic inflammatory disease as well as involves both innate and adaptive immune responses.Lipid-laden "foam cells" is primary component of the earliest atherosclerotic lesions.Ac
【机 构】
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School of Basic Course,Guangdong Pharmaceutical University,Guangzhou,510006,PR China
【出 处】
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世界中医药学会联合会中药药理专业委员会第七届学术会议、全国中药药理联合会第二届学术年会暨第20届中日健康学术研讨会
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Atherosclerosis is a chronic inflammatory disease as well as involves both innate and adaptive immune responses.Lipid-laden "foam cells" is primary component of the earliest atherosclerotic lesions.Act1,known as NF-κB activator 1,lies upstream of IKK and JNK,and mainly mediates classic IL-17/NF-κB signaling pathway.However,whether Act1 involved in the development of atherosclerosis was still unknown.Our data demonstrated that specific Act1 inhibition in macrophages effectively reduces atherosclerotic plaque in vivo and foam cell formation induced by ox-LDL in vitro.Furthermore,Actl inhibition decreases foam cell formation by suppressing ox-LDL uptake via CD-36-dependent pathway in peritoneal macrophages.
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