【摘 要】
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Atherosclerosis is a multifactofial and progressive disease commonly correlated with high fat diet.The aim of this study was to identify potential biomarkers for the early diagnosis and progression of
【机 构】
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Vascular Biology Research Institute,Guangdong Pharmaceutical University,Guangzhou 510006,PR China; S
【出 处】
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世界中医药学会联合会中药药理专业委员会第七届学术会议、全国中药药理联合会第二届学术年会暨第20届中日健康学术研讨会
论文部分内容阅读
Atherosclerosis is a multifactofial and progressive disease commonly correlated with high fat diet.The aim of this study was to identify potential biomarkers for the early diagnosis and progression of atherogenesis in apoE-/-mice by use of 1H NMR-based metabonomics.The apoE-/-mice were designed as four groups according to the high fat feeding time (0w,2w,4w and 8w),which possessed different pathological characteristics.Serum 1H NMR-based metabonomics selectively captured part of the metabotypes correlated with the degree of atherosclerosis,showing a time-dependent progression from physiological to pathophysiological status.
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