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Background It is well known synthetic mesh cannot be applied to contaminated hernia repair.For the ventral hernia repair, most scholars believed that the operation should be terminated or biological mesh should be used when the separation of severe bowel adhesions caused contamination.The synthetic mesh for contaminated fields has remained a heavily debated topic, at least, it was not recommended.To investigate the safety and feasibility of synthetic mesh in contaminated ventral hernia repair, we retrospectively analyzed 19 patients.