TGF-β Regulated miR-1868 Promotes Angiogenesis through Targeting PTEN in Endothelium

• 作 者: JunWang;YouliangWang;YuWang;YingMa;YuLan;XiaoYang;
• 机 构: State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Bio
• 出 处: 2012全国发育生物学大会
• 发表日期: 2012年期

　　The transforming growth factor-β (TGF-β) pathway plays important roles in physiological and pathological angiogenesis.MicroRNAs (miRNAs) are a class of 18-25 nucleotides small noncoding RNAs that function by negatively regulating gene expression.Numbers of miRNAs have been found to be regulated by TGF-β pathway.However, the role of endothelial miRNAs in the TGF-β-mediated control of angiogenesis is still largely unknown.Here we investigated the regulation of endothelial microRNA-1868 (miR-1868) by TGF-β signaling and the potential role of miR-1868 in angiogenesis.