Structural basis of human γ-secretase assembly

来源 :第四届全国冷冻电子显微学与结构生物学专题研讨会 | 被引量 : 0次 | 上传用户：hesion001

【摘要】

：

The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimers disease.Despite recent structural advances,the tra

【作者】

：

Linfeng Sun Lingyun Zhao Guanghui Yang Chuangye Yan Rui Zhou Xiaoyuan Zhou Tian Xie Yanyu Zhao Shenjie Wu Xueming Li Yigong Shi

【机构】

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SchoolofLifeSciences,TsinghuaUniversityMinistryofEducationKeyLaboratoryofProteinScience,Tsinghua-Pek

【出处】

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第四届全国冷冻电子显微学与结构生物学专题研讨会

【发表日期】

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2015年6期

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The four-component intramembrane protease γ-secretase is intricately linked to the development of Alzheimers disease.Despite recent structural advances,the transmembrane segments(TMs) of γ-secretase remain to be specifically assigned.

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Structural basis of human γ-secretase assembly

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