Wnt5a enhances the response of CML cells to Imatinib Mesylate through JNK activation and gama-cateni

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户：zhengzhidelang

【摘要】

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【作者】

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Chang-Chun Niu Chen Zhao Wei-Ke Si

【机构】

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Departments of Clinical Hematology,the Affiliated Southwest Hospital of the Third Military Medical U

【出处】

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The 35th World Congress of the International Society of Hema

【发表日期】

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2014年5期

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Imatinib Mesylate is widely used for the treatment of chronic myelogenous leukaemia (CML),and its effects on CML cells are influenced by several signalling proteins.The research is aimed at determining whether Wnt5a affects the effects of Imatinib Mesylate against BCR-ABL positive CML cells (K562 cells and KU812 cells) and which signalling proteins are involved in.

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Wnt5a enhances the response of CML cells to Imatinib Mesylate through JNK activation and gama-cateni

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