microRNA-34c/PI3K-Akt调控环路在Vaspin调节MC3T3-E1细胞成骨细胞分化中的作用机制研究

来源 :中华医学会第十二次全国内分泌学学术会议 | 被引量 : 0次 | 上传用户：xuwei1st

【摘要】

：

目的:研究发现,脂肪组织对骨代谢作用较为复杂,既往认为脂肪是骨骼的保护因子,然而最近的研究证实,脂肪组织可能在骨代谢的调节中发挥着负性的作用,而其分泌的脂肪因子是最重要的机制.本实验通过研究新发现的脂肪因子Vaspin对小鼠前成骨细胞MC3T3-E1成骨分化的影响,并观察miR-34c和PI3K-Akt信号通路在此过程中的作用,旨在阐明Vaspin调控成骨细胞分化的机制,为骨质疏松的预防和治疗提供

【作者】

：

袁凌青刘嫒廖二元

【机构】

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中南大学湘雅二医院代谢内分泌研究所 410011

【出处】

：

中华医学会第十二次全国内分泌学学术会议

【发表日期】

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2013年7期

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