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  5. Targeting human Vγ9Vδ2-T cells to control Epstein-Barr virus-induced B cell lymphoproliferative dise

Targeting human Vγ9Vδ2-T cells to control Epstein-Barr virus-induced B cell lymphoproliferative dise

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：spacelion
【摘 要】
：
Epstein-Barr virus-induced lymphoproliferative disease (EBV-LPD) after transplantation remains a serious and lifethreatening complication.Here, we showed that the aminobisphosphonate pamidronate-expan
【作 者】
：
Zheng Xiang Yinping Liu Jian Zheng Aizhen Lv Yulong Gao Kowk-Tai Lam Godfrey Chi-Fung Chan Yu-Lung Lau Wenwei Tu 
【机 构】
：
Laboratory for Translational Immunology, Department of Pediatrics & Adolescent Medicine, Li Ka Shing
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
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Epstein-Barr virus-induced lymphoproliferative disease (EBV-LPD) after transplantation remains a serious and lifethreatening complication.Here, we showed that the aminobisphosphonate pamidronate-expanded human Vγ9Vδ2-T cells efficiently killed EBV-transformed autologous lymphoblastoid B cell lines (EBV-LCL) in vitro through cell-celt contact,and γ/δ-TCR and NKG2D receptor triggering.The engagement of Fas and TRAIL, and release of perforin and granzyme contributed to the killing activity.
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