【摘 要】
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目的：探讨p38MAPK与假体周围颗粒诱导炎性骨溶解之间的关系.方法：钛颗粒刺激体外培养的RAW246.7细胞,用SB203580干预,Western blot检测p-p38mapk蛋白表达,ELISA检测细胞分
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目的：探讨p38MAPK与假体周围颗粒诱导炎性骨溶解之间的关系.方法：钛颗粒刺激体外培养的RAW246.7细胞,用SB203580干预,Western blot检测p-p38mapk蛋白表达,ELISA检测细胞分泌TNF-a,IL-6水平.结果：钛颗粒刺激细胞培养组(B组)比较于没有用颗粒刺激的正常培养组(A组),p-p38mapk蛋白含量,以及培养液上清中TNF-a,IL-6含量都明显升高(p＜0.05)；当细胞用钛颗粒刺激,同时加入SB203580(即C组),与B组比较,p-p38mapk却明显得到了抑制(p＜0.05),以及培养液上清中TNF-a,IL-6含量都明显下降(p＜0.05)；当C组与A组比较,p-p38mapk明显得到了抑制(p＜0.05),培养液上清中TNF-a,IL-6含量亦有所减少,但没有明显的统计学差异(p＞0.05).
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