The Size Effect of Poly (y, L-Glutamic Acid) (y-PGA) Based Cisplatin-Loaded Nanoparticles on Hela Ce

• 作 者: Yazhou Chen Shiming Tan Huasheng Zhang Zhi Wang Zirong Wu Jing Huang
• 机 构: School of Life Science, East China Normal University, Shanghai, China
• 出 处: 纳米药物及纳米生物技术国际学术大会暨中国药学会纳米药物专业委员会成立大会
• 发表日期: 2015年11期

A cisplatin-loaded nanoparticle composed of poly (Y, L-glutamic acid) (Y-PGA) and L-phenylalanine ethylester (L-PAE)was successfully synthesized as tumor-targeted drug carrier with sustained release capacity [1] We regulated the nanoparticles size by changing the y-PGA molecular weight, and evaluated its size effect on antitumor activity [2].