Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：ccj5310110

【摘要】

：

The scalable semisynthesis of ouabagenin, a bioactive cardenolide, has been achieved in 21 steps and 0.48％ overall yield starting from cortisone acetate.The use

【作者】

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Qianghui Zhou Hans Renata Phil S.Baran

【机构】

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DepartmentofChemistry,TheScrippsResearchInstitute,LaJolla,California,92037,USA

【出处】

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The 24th International Society of Heterocyclic Chemistry Con

【发表日期】

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2013年9期

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The scalable semisynthesis of ouabagenin, a bioactive cardenolide, has been achieved in 21 steps and 0.48％ overall yield starting from cortisone acetate.The use of two ketones in adrenosterone as handles for carrying out a number of key oxidations (redox relays) stereoselectively enables this concise and efficient synthesis.

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Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin

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