Efficacy of Osthole in retina of a chronic cerebral hypoperfusion rat model

来源 :首都医科大学第四届研究生学术论坛第二分论坛 | 被引量 : 0次 | 上传用户：xiekc

【摘要】

：

【作者】

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Ran DU Jia-lin Wang Yan-ling Wang

【机构】

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Department of Ophthalmology, Beijing Friendship hospital, Capital Medical University,Beijing, People

【出处】

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首都医科大学第四届研究生学术论坛第二分论坛

【发表日期】

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2016年8期

【关键词】

：

Chronic cerebral ischemia Carotid artery stenosis retinal vessals Osthole Aspiri

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　　Purpose: To determine effectiveness of osthole in retina of a chronic cerebral hypoperfusion (CCH) rat model,and detect potential mechanism involved in it.Methods: 72 rats were randomly allocated into 6 groups.CCH was induced in the rats by permanent bilateral common carotid artery occlusion (BCCAO).4 rats from each group were sacrificed every 5 days after drug administration.Histopathology and morphology of retina were observed.Akt,NF-K B,Bax and bcl-2 levels in retinal specimens were assessed using immunohistochemistry,immunofluorescence and reverse-transcription PCR.

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Efficacy of Osthole in retina of a chronic cerebral hypoperfusion rat model

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