【摘 要】
：
The hetero-pentameric (α4)2(β2)3 and homo-pentameric (α7)5 neuronal acetylcholine receptors (nAChRs) are representative of two important subtype nAChRs t
【机 构】
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UniversityofPittsburghSchoolofMedicineUSA
【出 处】
：
2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
The hetero-pentameric (α4)2(β2)3 and homo-pentameric (α7)5 neuronal acetylcholine receptors (nAChRs) are representative of two important subtype nAChRs that account for most of high-affinity binding sites in the central nervous system for nicotine and α-bungarotoxin,respectively.Despite their sequence homologous,(α4)2(β2)3 is supersensitive to inhibition by volatile anesthetics,whereas the (α7)5 is insensitive to these low-atfinity drugs.To understand how anesthetics modulate the receptor function,we studied the effects of halothane and isoflurane on full-length transmembrane (TM) domains of (α4)2(β2)3 and (α7)5 in a membrane mimetic environment.
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