【摘 要】
：
Chronic myeloid leukemia (CML) results from expression of the constitutive tyrosine kinase activity of the BCR-ABL oncoprotien.Imatinib mesylate (IM), a molecularly targeted drug which inhibits the ty
【机 构】
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Human Genome Center University Sains Malaysia Malaysia
论文部分内容阅读
Chronic myeloid leukemia (CML) results from expression of the constitutive tyrosine kinase activity of the BCR-ABL oncoprotien.Imatinib mesylate (IM), a molecularly targeted drug which inhibits the tyrosine kinase activity, is the current first line treatment for CML.However, a significant proportion of IM treated CML patients respond sub-optimally or develop resistance to IM.
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