【摘 要】
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PERP (p53 apoptosis effector related to PMP-22) is an apoptosis-specific effector of the major tumour suppressor p53.Down-regulation of PERP, both at transc
【机 构】
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Faculty of Health and Life Sciences University of Liverpool
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PERP (p53 apoptosis effector related to PMP-22) is an apoptosis-specific effector of the major tumour suppressor p53.Down-regulation of PERP, both at transcriptional and protein level, correlates with the aggressive (monosomy 3) type ofuveal melanoma (UM), the most common primary intraoculax tumour in adults in which p53 mutations are rare.Although p53 pathway is reportedly impaired in UM, this does not appear to be due to defects upstream or at the level of p53, therefore pointing towards deregulation of the pathway downstream of p53.Green-fluorescent protein (GFP)-PERP alongside fluorescent protein fusion constructs of p53 and p53-interacting proteins were engineered and used for transfection of UM cells and other ocular pigmented and control cells.
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