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Increasing evidences have indicated that there is a reciprocal modulation between central nervous system and immune system.However,how the immune signals,such as IL-1β,are transmitted into brain is still an unsolved question.It has been established that the mammalian carotid body (CB) is a polymodal sensor not only for sensation of hypoxia,but also for arterial low glucose and temperature as well.Our previous work has demonstrated morphologically that the glomus cells of normal rat CB strongly express IL-1 receptor type Ⅰ (IL-1RI).In present study,we investigated the effects of IL-1β on the electrophysiologic characteristics and the [Ca2+]i of CB glomus cells and on firings of the carotid sinus nerve (CSN).