Analysis of drug-resistant mutants induced by adefovir dipivoxil in patients with chronic HBV infect

• 作 者: Ai-RongHu[1]Su-WenJiang[2]Li-PengYao[3]Yao-RenHu[2]TaoXiong[2]Guo-ShengGao[2]Xiao-YueLiang[2]Shi-XiongDing[2]
• 机 构: Institute of Liver Diseases, Ningbo No.2 Hospital, Ningbo 315010, China
• 出 处: 第六届中国医师协会感染科医师大会暨传染病诊治高峰论坛、第十四届中华预防医学会微生态学学术会议
• 发表日期: 2014年期

　　Objective The treatment of liver diseases associated with chronic hepatitis B virus (HBV) infection has become a major clinical challenge, partly due to the many drug-resistant HBV mutants induced by wide application of nucleoside/nucleotide analogues.Currently the rate of resistance to adefovir dipivoxil (ADV) is relatively low, but in China is steadily increasing.We investigated the loci of ADV-induced resistance of HBV isolates obtained from patients with chronic HBV infection-related liver diseases.