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Objective It has been demonstrated that statin treatment alone significant increases plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels, which limited its lipid-lowering effect.Policosanal is a natural nutritional supplement used primarily for cholesterol lowering which has little side-effects.The effect of policosanol combined with statin on lipid profile as well as PCSK9 in Chinese patients with atherosclerosis is still unknown.