【摘 要】
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Objectives: The results of studies on association between KIR(killer cell immunoglobulin-like receptors)polymorphisms and susceptibility to RA(rheumatoid arthritis)are inconsistent.To comprehensively
【机 构】
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Department of Epidemiology and Biostatistics,School of Public Health,Anhui Medical University,81 Mei
【出 处】
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2015年安徽省流行病与卫生统计学学术论坛
论文部分内容阅读
Objectives: The results of studies on association between KIR(killer cell immunoglobulin-like receptors)polymorphisms and susceptibility to RA(rheumatoid arthritis)are inconsistent.To comprehensively evaluate the effect of KIR polymorphisms on the risk of RA,a meta-analysis was carried out.Methods: The Web of Science,PubMed,the Chinese Biomedical Database(CBM)and Chinese National Knowledge Infrastructure(CNKI)databases were systematically searched to select studies on the association between KIR polymorphisms and RA.The odds ratio(OR)with 95%confidence interval(95%CI)was obtained.Results: Nine qualified case–control studies were included in this meta-analysis.The results showed there were two positive associations of 2DL1,2DS1(OR2DL1 = 2.20,95%CI = 1.20–4.01,Praw = 0.01,PFDR = 0.03; OR2DS1 = 1.84,95%CI = 1.19–2.85,Praw = 0.006,PFDR = 0.018)and one negative association of 2DL3(OR2DL3 = 0.42,95%CI = 0.22–0.79,Praw = 0.006,PFDR = 0.018)with susceptibility to RA in East Asians,but not in Caucasians.Conclusion: The current meta-analysis provides evidence that 2DL3 might be a potential protective factor and 2DL1,2DS1 might be risk factors for RA in East Asians but not in Caucasians.
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