Methylenetetrahydrofolate reductase (MTHFR) polymorphism susceptibility to schizophrenia and bipolar

• 作 者: Cai-Yun Hu Zhen-Zhong Qian Feng-Feng Gong Shan-Shan Lu Fang Feng Yi-Le Wu Hui-Yun Yang Ye-Huan Sun
• 机 构: Department of Epidemiology and Health Statistics,School of Public Health,Anhui Medical University,No
• 出 处: 2015年安徽省流行病与卫生统计学学术论坛
• 发表日期: 2015年10期
• 关键词: Methylenetetrahydrofolate reductase MTHFR Polymorphism Schizophrenia Bipolar dis

　　Previous studies examining the possible role of the methylenetetrahydrofolate reductase(MTHFR)polymorphisms in the development of schizophrenia(SZ)and bipolar disorder(BPD)have provided inconclusive findings,this meta-analysis was therefore designed to get a more reliable assessment.A total of 38 articles were identified through a search of electronic databases,up to 27 February 2014.Odds ratios(ORs)with 95%confidence interval(CIs)were calculated using random effects models.Meta-analysis showed that MTHFR C677T was significantly associated with SZ,the highest OR was found for the recessive model(for TT vs.CT - CC: OR = 1.34,95%CI: 1.18–1.53); a marginal association of MTHFR C677T with increased risk of BPD has also been found for the recessive model(OR = 1.26,95%CI: 1.00–1.59).Subgroup analysis by ethnicity indicated that the significant association with SZ and BPD existed among Asian and African populations,but not for the white.MTHFR A1298C was significant associated with SZ,the highest OR for the dominant model(OR = 1.13,95%CI: 1.03–1.24).Subgroup analysis indicated a significant association with SZ existed in Asian populations,not among the white populations and no significant association was detected between the MTHFR A1298C and BPD in all groups.We conclude that MTHFR polymorphism is associated with SZ and BPD among Asian,African populations,but not the white.