【摘 要】
：
To enhance the dissolution and oral absorption of water insoluble drug sirolimus (SRL),self-microemulsifying pellets of SRL were developed and evaluated.Solubility test,self-emulsifying grading test,t
【机 构】
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Department of Pharmacy,Fuzhou General Hospital of Nanjing Military Region,Fuzhou 350025,China;School
【出 处】
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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
论文部分内容阅读
To enhance the dissolution and oral absorption of water insoluble drug sirolimus (SRL),self-microemulsifying pellets of SRL were developed and evaluated.Solubility test,self-emulsifying grading test,ternary phase diagrams,and central composite design were adopted to screen and optimize the composition of liquid SRL-SMEDDS.The selected liquid SRL-SMEDDS formulations were prepared into pellets by extrusion-spheronization method and the optimal formulation of lmg SRL-SMEDDS pellets capsule (1.0,22.4,38.4,19.2,121.6,30.4 and 8.0 mg of SRL,Labrafil M1944CS,Cremophor EL,Transcutol P,MCC,Lactose and CMS-Na,respectively) was finally determinated by the feasibility of the preparing process and redispersibility.
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