Pharmacokinetic and pharmacodynamic properties of batifiban coadministered with antithrombin agents

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：windFWF1992

【摘要】

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【作者】

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Xiao-meng HE Yao-hua WANG Wei-yong LI Ying ZHOU Jie LI San-lan WU Meng-meng JIA Ming-zhou LIU Hui CHEN Ke CHEN Sheng-feng LI

【机构】

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Institute of Clinical Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Scien

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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batifiban glycoprotein Ⅱb-Ⅲa inhibitors antithrombin agents pharmacokinetics pha

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Aim: To observe whether antithrombin agents affects the pharmacokinetic and pharmacodynamic properties of batifiban in combination therapy and optimize clinical administration dosage of batifiban.Methods: An open-label, parallel study was conducted.Thirty healthy subjects were randomly divided into three groups, which were sequentially treated with batifiban alone, or oral coadministration of clopidogrel, aspirin and UFH, or batifiban coadministered with these antithrombin agents.Blood samples were collected at pre-specified times.

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Pharmacokinetic and pharmacodynamic properties of batifiban coadministered with antithrombin agents

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