【摘 要】
：
Background Pathogenesis of Crohns disease (CD) is supposed to result from interactions between genetic predisposition, environmental triggers and mucosal immuni
【机 构】
：
ZhongshanHospitalaffiliatedtoXiamenUniversity,Xiamen,FujianProvince
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
论文部分内容阅读
Background Pathogenesis of Crohns disease (CD) is supposed to result from interactions between genetic predisposition, environmental triggers and mucosal immunity.The previous studies have highlighted the role of genetic predispositions, and several genes had been identified as important causing gene, such as NOD2/CARD15, IL23R, ATG16L1 and PTPN2.However, most of them might be rare and not be associated with susceptibility to CD in Chinese patients, suggesting possible genetic heterogeneity of CD in different populations.So far, no reports have determined the specific susceptibility genes in Chinese patients.
其他文献
目的 明确B7-H4分子在C3H10细胞移植治疗小鼠EAE模型的体内效应.方法 1、构建B7-H4靶向shRNA转染的C3H10细胞(C3H10-shRNA),应用免疫荧光标记、流式细胞术检测B7-H4表达下调
The profile of T cell receptor beta variable (TCRBV) usually skewed in subjects with virus infection or cancer.The gene melting spectral pattern (GMSP) can be u
Background & Aims Interleukin-22 (IL-22) is up-regulated in liver tissues of patients with hepatitis C virus (HCV) and demonstrates anti-fibrotic functions in m
Background Patients with active ulcerative colitis (UC) have elevated and activated myeloid lineage leucocytes, notably the CD 14 (+)CD16(+) monocyte phenotype,
Aim Multidmg resistance (MDR) remains the major reason for the treatment failure in gastric cancer (GC).microRNAs (miRNAs) were recently found to play critical
Aim The dysregulated cytokine metabolism and activity are crucial to the development of fulminant hepatic failure (FHF), and many different cytokines have been
目的 OSST多中心随机对照研究表明,对于长期服用恩替卡韦治疗而没有获得HBeAg血清学转换的慢乙肝患者,采用恩替卡韦与长效干扰素(Peg-IFN) alfa-2a联合/序贯治疗组(短暂联合8
Phosphorylation of phosphatase and tensin homolog (PTEN) at residues Ser380/Thr382/383 is an important post-translational modification, which results in the los
Aim Dendritic cells (DCs) significantly contribute to the pathology of several chronic inflammatory autoimmune disorders.However,little is known of the contribu
Objectives Detection of early cancer or pre-cancerous lesions is crucial for outcome of patients with risks of early gastric carcinoma (EGC).Detection rate high