【摘 要】
：
The DNA damage-response pathway is essential for the maintenance of genomic stability; as a result, it acts as the barrier for tumorigenesis.Previous studie
【机 构】
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Baylor College of Medicine USA
【出 处】
：
BIT Life Sciences' 1st Annual World Cancer Congess-2008(
论文部分内容阅读
The DNA damage-response pathway is essential for the maintenance of genomic stability; as a result, it acts as the barrier for tumorigenesis.Previous studies in cell culture demonstrated that Britl played critical roles in checkpoint control and DNA damage response.Aberrant expression of Britl was also identified in several types of human cancers.To address the physiological functions of Brit1 and the effect of its deficiency on tumorigenesis, we recently generated a Brit1 knockout (Brit1-/-) mouse model and analyzed its in vivo function.We found that Brit1-/-mice can survive to adulthood but with growth retardation and low birth rate.Both Brit1-/-male and female mice were infertile with much smaller testes or ovaries.
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