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  5. ADAMTS9, Located at the Critical Tumor Suppressor Locus 3p14, is Silenced by CpG Methylation in Brea

ADAMTS9, Located at the Critical Tumor Suppressor Locus 3p14, is Silenced by CpG Methylation in Brea

来源 :2011第四届世界癌症大会暨乳腺癌峰会 | 被引量 : 0次 | 上传用户：chenming88623
【摘 要】
：
ADAMTS9, a member of the large family of 19 metalloproteases, was ubiquitously detected in all human fetal and adult tissues.Recent studies have revealed that ADAMTS9 is a tumor suppressor inactivated
【作 者】
：
Tingxiu Xiang Lili Li Xuedong Yin Guosheng Ren Qian Tao 
【机 构】
：
Molecular Oncology and Epigenetics Laboratory The First Affiliated Hospital of Chongqing Medical Uni
【出 处】
：
2011第四届世界癌症大会暨乳腺癌峰会
【发表日期】
：
2011年3期
【关键词】
：
ADAMTS9 promoter methylation tumor suppressor gene breast cancer 
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　　ADAMTS9, a member of the large family of 19 metalloproteases, was ubiquitously detected in all human fetal and adult tissues.Recent studies have revealed that ADAMTS9 is a tumor suppressor inactivated by aberrant promoter methylation in esophageal and nasopharyngeal carcinomas, while nothing is known about its role and alterations in breast cancer pathogenesis.In this study, we analyzed ADAMTS9 expression and methylation status in breast cancer cell lines and tumor tissues.
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