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  5. Modulation of Estrogen Synthesis and Metabolism Pathways by Cabbage Juices and Their Active Componen

Modulation of Estrogen Synthesis and Metabolism Pathways by Cabbage Juices and Their Active Componen

来源 :2011第四届世界癌症大会 | 被引量 : 0次 | 上传用户：homejang
【摘 要】
：
Breast cancer is the leading cause of death in females between the age of 40 to 50 in the Western world.Iccreased lifetime exposure to estrogens, particularly produced in situ, is recognized as the mo
【作 者】
：
Wanda Baer-Dubowska Barbara Licznerska Hanna Szaefer 
【机 构】
：
Department of Pharmaceutical Biochemistry Poznan University of Medical Sciences Poland
【出 处】
：
2011第四届世界癌症大会
【发表日期】
：
2011年3期
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　　Breast cancer is the leading cause of death in females between the age of 40 to 50 in the Western world.Iccreased lifetime exposure to estrogens, particularly produced in situ, is recognized as the most important factor in breast cancer development.Estrogens not only can promote cancers but the products of their metabolism may also initiate breast tumorigenesis.Aromatase, encoded by CYP1 9 gene, as well as sulfatase (STS) and 17β-hydroxysteroid dehydrogenase (HSD17b1) are involved in the in situ synthesis of estrogens.
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