Cde42 inhibitor ML141 enhances G-CSF-induced hematopoietic stem and progenitor cell mobilization

• 作 者: 陈翀;
• 机 构: 徐州医学院附属医院血液科
• 出 处: 第十五届全国实验血液学学术会议
• 发表日期: 2015年期

　　G-CSF is the most often used in clinical hematopoietic stem and progenitor cells (HSPC) mobilization.However, G-CSF could not efficiently mobilize enough HSPC in about 10% patients.Cdc42 activity is involved in HSPC mobilization.Herein, we explore the impact of Cdc42 inhibitor ML141 on G-CSF mediated HSPC mobilization in mice.We found that using ML141 alone only presented modest HSPC mobilization effect in mice.