An Efficient Process for the Synthesis of 2-Perfluoroalkylated 2H-Chromenes via Methyl Perfluoroalk-

来源 :中国化学会第30届学术年会 | 被引量 : 0次 | 上传用户:fjms001
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Functionalized chromenes have received considerable attention due to their wide range biological and pharmacological activities1.It is also an important class of compounds which are constituent of the structural unit of a series of biological active natural products and drugs2.Thus,we report here an efficient method for the synthesis of 2-perfluoroalkyl-2-hydroxy-2H-chromene-3-carboxylates 3 involving a one-pot reaction of substituted salicylaldehydes 1 and methyl perfluoroalk-2-ynoates 2 in the presence of L-proline.
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