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Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism with chronic anovulation and is currently one of the most common endocrinopaties in childbearing women.PCOS is associated with a variety of endocrine and metabolic disturbances.It is well known that women prone to develop autoimmune diseases more frequently compared to men and levels of sexual hormones are thought to be responsible for such a difference.Our aim is to prove that women with PCOS are more prone for autoimmune diseases despite their hyperandrogenism.It was already demonstrated that the prevalence of autoimmune thyroiditis is 3fold higher among these patients.Recent studies reveal a higher incidence of autoantibodies such as antihistone, anti dsDNA presented in systemic autoimmune disease, however their clinical significance is still unknown.Materials and method: We analyzed sera of 180 patients with PCOS using commercially available kits for presence of various autoantibodies (such as ANA, ENA, aTPO, aTG, ANCA, ACLA) known in systemic and organ specific autoimmune diseases and compared it with 43 healthy controls.Moreover we tried to prove presence of anti-ovarian autoantibodies in patients sera what could mean that disease is autoimmune itself.Results: we found specific differences between the presence of systemic autoantibodies in patients sera compared to controls.Significant difference was seen in presence of antibodies typical for Hashimoto tyreoiditis.Only in some PCOS patients we could observe a tendency to bind ovarian cancer cell-lines meaning there could be a subgroup of PCOS autoimmune mediated.Clinical significance is still uknown and whether these patients will develop autoimmune disease in future remains unclear.It raises a question of hormonal influence on immune system.