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Previous studies have reported that selective serotonin reuptake inhibitors (SSRIs) might induce or exacerbate periodic limb movement during sleep (PLMS).However,most of them were retrospective and cross-sectional studies with small sample size on a selective SSRI,Fluoxetine.As different SSRIs have different pharmacological profiles,it was not certain whether other SSRIs might also lead to PLMS.