In vivo patients' evidence that NTCP is a receptor for HBV

来源 :第十四次全国医学遗传学学术会议 | 被引量 : 0次 | 上传用户：oyocean1

【摘要】

：

　　In the past 50 years there have been considerable efforts to identify the cellular receptor of hepatitis B virus (HBV).Recently, in vitro evidence from seve

【作者】

：

刘瑞虹;

【机构】

：

中山大学中山医学院医学遗传学教研室

【出处】

：

第十四次全国医学遗传学学术会议

【发表日期】

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2015年期

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　　In the past 50 years there have been considerable efforts to identify the cellular receptor of hepatitis B virus (HBV).Recently, in vitro evidence from several groups has shown that the sodium-taurocholate cotransporting polypeptide (NTCP, which is encoded by SLC10A1 and transports bile acids into hepatic cells in enterohepatic recirculation)is a strong candidate.In particular, in vitro the p.Ser267Phe variation of SLC10A1 results in loss of HBV receptor function.

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In vivo patients' evidence that NTCP is a receptor for HBV

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