【摘 要】
：
Currently,detection methods for biomedical analysis rely primarily on optical,magnetic,or electrochemical measurements.However,considering the need for low-cost analyse by inexperienced personnel,for
【机 构】
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State Key Laboratory of Physical Chemistry of Solid Surfaces,The MOE Key Laboratory of Spectrochemic
【出 处】
：
2016年分析化学前沿国际研讨会及中美分析化学研讨会
论文部分内容阅读
Currently,detection methods for biomedical analysis rely primarily on optical,magnetic,or electrochemical measurements.However,considering the need for low-cost analyse by inexperienced personnel,for example in field operations or point-of-care scenarios,these methods suffer from inherent limitations.In this work,we demonstrated that a very familiar,yet underutilized,physical parameter—gas pressure—can serve as signal readout for highly sensitive medical detection and bioanalysis.Integration of a catalyzed gas generation reaction with a molecular recognition component leads to significant pressure changes,which can be measured with high sensitivity using a low-cost and portable pressure meter.In particular,we have combined the decomposition of H2O2 catalyzed by catalase or Pt nanoparticles with either an antibody-based sandwich assay or a target-responsive DNA hydrogel for detection of various analytes.This new signaling strategy opens up a new way for simple,rapid,portable,yet highly sensitive biomedical analysis in a variety of settings.
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