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Alzheimers dementia is a growing threat to the rapidly increasing elderly population worldwide.In the Philippines,there are 3.8 million people above 65 years old who are at risk of developing AD.This report presents the results of a cross-sectional study to determine the genotypic distribution of ApoE in affected and unaffected groups of Filipinos.who either consulted in the hospital for Alzheimers dementia,or were screened in a community setting.Peripheral blood was collected from a total of 600 subjects,composed of 124 patients who consulted at the Memory Center of St.Lukes Medical Center,Quezon City and 476 individuals who participated in a community-based cohort.