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Objective To investigate if elevated progesterone is associated with repeated IVF failure.Materials and Methods It is a single center, retrospective cohort study between January 2007 and August 2012.A total of 6,673 women consecutive undergoing IVF treatments were categorized into: Group I, no previous IVF treatment;Group Ⅱ, one previous IVF treatment failure; and Group Ⅲ, two or more previous IVF treatment failures.