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A large cohort study was carried out to determine that the aging was strong risk factor on hepatocarcinogenesis in spite of the stage of liver fibrosis.Several miRNAs have emerged as potentially coordinating multiple pathways during aging.We compared hepatic miRNA and mRNA expression profile in between chronic hepatitis C (CHC) and hepatocellular carcinoma (HCC) in order to elucidate the difference in the carcinogenetic mechanism according to age.