【摘 要】
：
TRPM2 is a Ca2+permeable non-selective cation channel gated by oxidative/nitrosative stress via production of ADP-ribose,an intracellular TRPM2 agonist.Our
【机 构】
：
Departmaent of Pharmacology & Therapeutics,University of Manitoba,Winnipeg,Manitoba
【出 处】
：
中国药理学会北美分会药理学学术大会
论文部分内容阅读
TRPM2 is a Ca2+permeable non-selective cation channel gated by oxidative/nitrosative stress via production of ADP-ribose,an intracellular TRPM2 agonist.Our past findings have shown that TRPM2 is functionally coupled to voltagegated Ca2+channels and NMDA receptors,regulates GSK3β and the expression of AMPA receptor subunits and is required for the induction of hippocampal NMDAR-dependent LTD.More recently,we established that genetic deletion of TRPM2 prevents Alzheimer's disease pathology and cognitive deficits in Alzheimer model mice.Although TRPM2 function is potentiated by treatment of cultured neurons with Aβ,the mechanism responsible has not been identified.One candidate mechanism is via tyrosine phosphorylation.Indeed,TRPM2 is regulated by tyrosine phosphatases.Moreover,Aβ is known to promote Fyn activity.
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