THE NLRP3-R258W MUTATION PROTECTS MICE FROM EXPERIMENTAL COLITIS

• 作 者: Xiaomin Yao Yue Xing Guangxun Meng
• 机 构: Unit of Innate Immunity, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China
• 出 处: The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会)
• 发表日期: 2015年11期

Dysregulation of innate immune reactions is involved in the development of Inflammatory bowel disease (IBD).As an important gene in the innate immune system, NLRP3 has been linked with IBD and colorectal cancer, but the research results are controversial.Using mice carrying the Nlrp3-R258W mutation which acquires an autoactivation of the NLRP3 inflammasome, we discovered that this mutation provided the mice with significant protection from DSS induced colitis.