【摘 要】
：
体外循环(cardiopulmonary bypass,CPB)可通过多种因素诱发全身性炎性反应,术后大量炎症介质释放入血可损伤心、肺、脑、肾等重要脏器,易引起器官衰竭和全身炎症反应综合征(Systemic inflammatory response syndrome,SIRS).小儿心脏病患者身体各系统发育不完善,对炎性反应的耐受及调节能力差,CPB所引发的SIRS对患儿心肺等脏器的影响更为明显
【机 构】
：
昆明医科大学第一附属医院麻醉科,云南,昆明650032
【出 处】
：
中国中西医结合麻醉学会年会暨第二届全国中西医结合麻醉学术研讨会
论文部分内容阅读
体外循环(cardiopulmonary bypass,CPB)可通过多种因素诱发全身性炎性反应,术后大量炎症介质释放入血可损伤心、肺、脑、肾等重要脏器,易引起器官衰竭和全身炎症反应综合征(Systemic inflammatory response syndrome,SIRS).小儿心脏病患者身体各系统发育不完善,对炎性反应的耐受及调节能力差,CPB所引发的SIRS对患儿心肺等脏器的影响更为明显,更容易导致多器官的功能不全[1].右美托咪啶作为一种新型的α 2肾上腺素能受体激动剂,不但可以抑制开胸手术中应激反应,而且还有较强的抗炎作用[2],但其对小儿CPB的炎性反应尚不清楚.本研究拟探讨右美托咪啶对小儿CPB围术期炎性反应的影响,为临床用药提供参考.
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