Recent evidence suggests that immunological memory does not only consist of memory lymphocytes circulating through the body, but that distinct and prominent populations of memory lymphocytes reside in
Innate immunity consists of a cellular and a humoral arm.The long pentraxin PTX3 as originally cloned (cDNA and genomics, mouse and human) as an IL-1 inducible gene.
TRAF family member-associated NF-κB activator (TANK) is a scaffold protein that assembles into the IRF3/7-phosphor-ylating TBK1-IKKε complex, where it is involved in regulating phosphorylation of the
Antibodies (Abs) preferentially targeting oncogenic receptors are increasingly used for cancer therapy, but tumors often develop Ab-resistance after prolonged and costly treatment.
Induction of the transcriptional repressor Bcl-6 in CD4+ T cells is critical for the differentiation of follicular helper T cells (TFH cells), which are essential for B cell-mediated immunity.
Hepatocellular carcinomas (HCCs) are among the leading causes of global cancer-related mortality.The key regulators or signaling events underlying these malignancies remain largely unknown.
Autoimmune diseases such as multiple sclerosis (MS) and type 1 diabetes (T 1 D) are resulted from the interaction of susceptible genes and environmental factors.
Background: Regulatory B cells have gained more and more attentions in that they modulate the immune response against autoimmune diseases, infectious diseases, and tumors.