Concise Synthesis of 6,7-Disubstituted 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibi

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：HappHapp

【摘要】

：

3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]-indol-1-ones(Ⅰ)were developed with the aid of protein structure-based drug design by Pfizer as the third generation of novel 5,6,7-tricyclic PARP-1 inhibitors.

【作者】

：

Zhoulong Fan Li Xing Wei Li Ao Zhang

【机构】

：

CAS Key Laboratory of Receptor Research,Shanghai Institute of Materia Medica(SIMM),Chinese Academy o

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

C-H activation phenidones PARP-1 3 4-Dihydro-2H-[1 4]diazepino[6 7 1-hi]indol-1-

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