阿托伐他汀对H9C2心肌细胞缺氧再复氧损伤的作用

来源 :2016年浙江省医学会心电生理与起搏学术年会 | 被引量 : 0次 | 上传用户:yughg
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  目的:观察阿托伐他汀对H9C2心肌细胞缺氧再复氧损伤的保护作用.方法:正常培养的H9C2细胞,分为6组,正常对照组、缺氧再复氧(H/R)组、Ator干预组(1、5、10、20um/ml),缺氧1小时,复氧2小时,然后测定CCK8判断细胞损伤程度.结果:缺氧复氧后,其余组与正常对照组相比,细胞活性均显著下降(p<0.05);Ator干预组(1、5、10、20um/ml)与缺氧再复氧组相比,细胞活性均有显著上升(p<0.05).结论:阿托伐他汀对H9C2心肌细胞缺氧再复氧损伤有一定的保护作用.
其他文献
In this work,we devised a novel gene transcript variant recognition and signal amplification model.The generation of a consecutive target due to alternative splicing of exon2 between exonl and cxon3 r
Gene transcript often varies by alternative splicing,which plays different biological role that results in diversity of gene expression.Therefore,a simple and accurate identification of targeted trans
目的:探讨急性心肌梗死急诊经皮冠脉介入治疗(PCI)患者T3水平与术后冠脉血流、心肌再灌注的关系和相关的影响因素,以及与心衰等心血管事件的关系,以指导临床实践.方法:回顾性收集205例急性心肌梗死急诊PCI患者,根据血清T3水平四分位数进行分组:A组((重度低T3组):0.4≤T3<0.93,n=51例;B组(中度低T3组):0.93≤T3<1.13,n=53例;C组(轻度低T3组):1.13≤T
Objects:We aimed to unveil the clinical roles and biological function of lncRNA RPLPOP2 in lung adenocarcinoma (LAD).Materials and methods:The expression level of RPLPOP2 was estimated by qPCR in 57 p
Background: Observational studies suggest an association between human papillomavirus (HPV) infection and risk of prostate cancer (PCa).However,the relationship between HPV infection and the risk of P
目的:以胶原诱导关节炎(CIA)大鼠为模型,观察二甲双胍对CIA大鼠血清细胞因子、脾脏辅助性T细胞17 (TH17)及调节性T细胞(Treg)分化的影响和脾脏AMPK、mTOR的表达,初步探讨二甲双胍治疗类风湿关节炎的可能机制。
会议
Objects:In recent years,chemotherapy outcome is usually poor because of drug resistance in cancer patients.It is an urgent concern for oncologist to investigate the mechanism and fimd a way to deal wi
Androgen deprivation therapy (ADT,surgical or chemical castration) is the mainstay treatment for metastatic PCa,but patients ineluctably relapse despite extremely low androgen levels.This evolution of
Aims: Rapidly growing evidence showsthatNLR family,pyrin domain containing 3 (NLRP3) inflammasome is closely related with the progression of atherosclerosis.The purpose of the present study was to ass
目的:探讨冠脉钙化积分在低危胸痛患者中对冠心病及冠脉病变范围是否有较高的诊断价值及评估能力。方法:从2012年1月-2014年12月因胸痛在温州医科大学附属第二医院心内科住院的病人中共筛选出303例,这些患者住院期间均做过冠脉钙化积分检查,且同时有做冠脉造影、冠脉CTA、运动平板试验中至少一项检查。从病案系统中获取患者的冠脉钙化积分、冠脉造影、冠脉CTA、运动平板试验结果,并登记性别、年龄、体重指