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Given the widespread use of aluminum oxide nanoparticles (A12O3 NPs), systematic tests for understanding the uncertain health aspects of Al2O3 NPs is necessary.In this study, ICR mice were used as in vivo model to assess the neurotoxicity of Al2O3 NPs, which were given to the mice through gavage (5g/kg weight) for once only and transnasal drip (50 mg/kg weight) for 30 days, mice treated with 0.9％ normal saline and alumina micro-particles were used as black and bulk controls.