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  5. Dual pH-responsive 5-aminolevulinic acid supramolecular prodrug micelles for enhanced photodynamic a

Dual pH-responsive 5-aminolevulinic acid supramolecular prodrug micelles for enhanced photodynamic a

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：Pkulibo
【摘 要】
：
Photodynamic therapy (PDT) is a promising modality for the treatment of cancer and many other diseases[1].5-Aminolevulinic acid (ALA),a FDA-approved PDT precursor of protoporphyrin Ⅸ (PplⅨ),is gaining
【作 者】
：
Hongxin Tong Qiao Jin Jian Ji 
【机 构】
：
MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science a
【出 处】
：
Fourth Symposium on Innovative Polymers for Controlled Deliv
【发表日期】
：
2016年11期
【关键词】
：
ALA photodynamic therapy host-guest interaction prodrug 
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　　Photodynamic therapy (PDT) is a promising modality for the treatment of cancer and many other diseases[1].5-Aminolevulinic acid (ALA),a FDA-approved PDT precursor of protoporphyrin Ⅸ (PplⅨ),is gaining increasing attention because of its nontoxicity and fast metabolization from biological systems.However,the internalization of ALA is a big challenge due to the hydrophilic nature and low specificity to cancer cells[2].
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