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Background The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy.Methods Fifty-one ACS patients were divided randomly into a probucol treatment group (P) and a routine treatment group (C).Oxidized low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method.The brachial arterial hyperemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation was measured by high resolution ultrasound.These variables were analyzed after received probucol 3months.