【摘 要】
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Objective To investigate the adverse effects of different doses of HPM irradiation on oxidative stress in the brain of Wistar rats, in order to provide basis for establishing an animal model to evalua
【机 构】
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Beijing Institute of Radiation Medicine,Academy of Military Medical Sciences, Beijing 100850, China
【出 处】
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第十四届中国体视学与图像分析学术会议
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Objective To investigate the adverse effects of different doses of HPM irradiation on oxidative stress in the brain of Wistar rats, in order to provide basis for establishing an animal model to evaluateprotective agents which will be used for protection against microwave radiation.Methods Eighty male Wistar rats were randomly divided into 16 groups according to the factor analysis.The average power density were 0mW/cm2 、10mW/cm2 、30mW/cm2and 100mW/cm2 and the sampling time were 6h、ld、3d、7d.The duration of exposure was 6 minutes for each radiation group.After exposure, the rats were sacrificed at each sampling time.Colorimetric method was used to measure the content of MDA, protein carbonyl content,the activity of GSH-px, SOD and CAT.Results The MDA and protein carbonyl content of each radiation group were basically increasedwith the radiation dose increased, and they decreased with the sampling time prolonged.The activity of SOD、GSH-px、 CAT in each radiation group werebasically decreased with the radiation dose increased, and with the sampling time prolonged, they first decreased and then increased.Conclusion Microwave radiation can cause oxidative stress in rats brain, mainly in the oxidative damage of lipid and protein and the decrease of the activity of antioxidant enzymes.Besides, it has a certain dependence with the radiation dose and sampling time.
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