Effect of intrathecal injection of Staurosporine on spinal microglia activation in ratswith bone can

来源 :中华医学会第22次全国麻醉学术年会 | 被引量 : 0次 | 上传用户：liguang1233000

【摘要】

：

【作者】

：

CHEN Yong DU Xiao-hong YING Jun LIANG Ying-ping HU Yan-hui XU Guo-hai

【机构】

：

Department of Anesthesiology, Second Affiliated Hospital of Nanchang University, Nanchang 330006, Ch

【出处】

：

中华医学会第22次全国麻醉学术年会

【发表日期】

：

2014年11期

【关键词】

：

Protein kinase C Bone neoplasms Pain Microglia Spinal cord

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Objective To investigate the effect of intrathecal injection with PKC inhibitor Staurosporine on pain behaviour and spinal microglia activation in rats with shin bone cancer pain.Methods One hundred and twenty adult male SD rats weighting 200-250g were randomly divided into 5 groups (n=24): group control (group C),group model (group M),group normal saline (group N),group solvent (group S) and group Staurosporine (group SP).

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Effect of intrathecal injection of Staurosporine on spinal microglia activation in ratswith bone can

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