【摘 要】
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In Europe, per year, 1.5 million patients undergo external radiotherapy.The late adverse effect of radiotherapy concern 5 to 10% of them.Eradication of these manifestations is crucial.We are strongly
【机 构】
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Institute of Nuclear Safety and Radioprotection (IRSN) France
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In Europe, per year, 1.5 million patients undergo external radiotherapy.The late adverse effect of radiotherapy concern 5 to 10% of them.Eradication of these manifestations is crucial.We are strongly implicated in the field of regeneration of healthy tissue after radiotherapy or radiological accident.In 2004, in collaboration with Saint-Antoine Hospital (Paris, France),our first success in cell therapy was the correction of deficient haematopoiesis in two patients.The intravenous injection of Mesenchymal Stem Cells (MSC) has restored bone marrow micro-environnement necessary to sustain haematopoiesis after total body irradiation.From 2006 until 2011, we have obtained foremost success in cell therapy of radiation induced bums.In collaboration with the Percy hospital (Clamart, France) we have evidenced for the first time, the efficiency of MSC therapy in the context of acute cutaneous and muscle damage following irradiation in five patients.In 2007, we have also demonstrated that MSC treatment is a promise approach for the medical management of gastrointestinal disorder after irradiation.Three patients were successfully treated for consequences of over exposure for pelvic radiotherapy in 2007 and one patient in 2011.Evaluation of stem cell therapy combining different source of adult stem cells is under investigation.
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