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Cancer results from processes prone to selective pressure and dysregulation acting along the sequence-to-phenotype continuum DNA→RNA→protein→disease.However,the extent to which cancer is a manifestation of the proteome is unknown.Here we present an integrated omic map representing non-small cell lung carcinoma.Dysregulated proteins not previously implicated as cancer drivers are encoded throughout the genome including,but not limited to,regions of recurrent DNA amplification/deletion.Clustering reveals signatures composed of metabolism proteins particularly highly recapitulated between patient-matched primary and xenograft tumours.